• Bivariate genome-wide association meta-analysis of pediatric musculoskeletal traits reveals pleiotropic effects at the SREBF1/TOM1L2 locus 

      Medina-Gomez, Carolina; Kemp, John P.; Dimou, Niki L.; Kreiner, Eskil; Chesi, Alessandra; Zemel, Babette S.; Bønnelykke, Klaus; Boer, Cindy G.; Ahluwalia, Tarunveer S.; Bisgaard, Hans; Evangelou, Evangelos; Heppe, Denise H. M.; Bonewald, Lynda F.; Gorski, Jeffrey P.; Ghanbari, Mohsen; Demissie, Serkalem; Duque, Gustavo; Maurano, Matthew T.; Kiel, Douglas P.; Hsu, Yi-Hsiang; van der Erden, Bram C. J.; Ackert-Bicknell, Cheryl; Reppe, Sjur; Gautvik, Kaare M.; Raastad, Truls; Karasik, David; van de Peppel, Jeroen; Jaddoe, Vincent W. V.; Uitterlinden, Andre G.; Tobias, Jonathan H.; Grant, Struan F. A.; Bagos, Pantelis G.; Evans, David M.; Rivadeneira, Fernando (Journal article; Peer reviewed, 2017)
      Bone mineral density is known to be a heritable, polygenic trait whereas genetic variants contributing to lean mass variation remain largely unknown. We estimated the shared SNP heritability and performed a bivariate GWAS ...
    • Heavy-load exercise in older adults activates vasculogenesis and has a stronger impact on muscle gene expression than in young adults 

      Olstad, Ole Kristoffer; Raue, Ulrika; Gautvik, Vigdis Teig; Kvernevik, Karl Johnny; Utheim, Tor Paaske; Ravnum, Solveig; Kirkegaard, Camilla; Wiig, Håvard; Jones, Garan; Pilling, Luke C.; Trappe, Scott; Raastad, Truls; Reppe, Sjur; Gautvik, Kaare M. (Peer reviewed; Journal article, 2022)
      Background: A striking effect of old age is the involuntary loss of muscle mass and strength leading to sarcopenia and reduced physiological functions. However, effects of heavy-load exercise in older adults on diseases ...
    • Postmenopausal osteoporosis is a musculoskeletal disease with a common genetic trait which responds to strength training: a translational intervention study 

      Olstad, Ole Kristoffer; Gautvik, Vigdis Teig; LeBlanc, Marissa Erin; Kvernevik, Karl Johnny; Utheim, Tor Paaske; Runningen, Anne; Wiig, Håvard; Kirkegaard, Camilla; Raastad, Truls; Reppe, Sjur; Gautvik, Kaare M. (Peer reviewed; Journal article, 2020)
      Background: Clinical evidence suggests that body muscle mass is positively associated with bone mass, of significance for the elderly population at risk of osteoporosis (OP). Furthermore, muscle and bone interact mechanically ...